Furin, a potential therapeutic target for COVID-19

分类： 医学、药学 >> 药学 提交时间： 2020-02-23

Hua Li Canrong Wu Yueying Yang Yang Liu Peng Zhang Yali Wang Qiqi Wang Yang Xu Mingxue Li Mengzhu Zheng Lixia Chen

摘要： A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through a series of analyses, we propose the reason why SARS-CoV-2is more infectious than other coronaviruses. And through structure based virtual ligand screening, we foundpotentialfurin inhibitors, which might be used in the treatment of new coronary pneumonia.

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